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Article

ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells

11 Jan 2019

Abstract excerpt

Werner syndrome (WS) is a cancer-prone disease caused by deficiency of Werner protein (WRN). WRN maintains genome integrity by promoting replication-fork stability after various forms of replication stress. Under mild replication stress, WS cells show impaired ATR-mediated CHK1 activation. However, it remains unclear if WS cells elicit other repair pathway. We demonstrate that loss of WRN leads to enhanced ATM...

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PMID: 30657978
DOI: 10.1093/nar/gkz025

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