Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation

Abstract excerpt

<h4>ABSTRACT</h4> Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood. Here we report that Usp16, a negative regulator of Bmi1/PRC1 function, modulates the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential. In mammary glands, reduced levels of Usp16 increase tissue responsiveness to Wnt, resulting in up...

Topics

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• Activin Receptors, Type I
• Bone Morphogenetic Proteins
• Cellular Reprogramming
• Cellular Senescence
• Cyclin-Dependent Kinase Inhibitor p16
• Down syndrome and intellectual disability research
• Induced Pluripotent Stem Cells
• Myositis Ossificans

Identifiers and source

Literature Corpus work

c71a0ccf-eb7a-5ded-8a76-60391286859a

DOI

10.1101/326272