Article
Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling
2021-02-03
Abstract excerpt
<title>Abstract</title> <p><bold>Background: </bold>The transforming growth factor-β (TGF-β) signaling pathway plays an essential role in maintaining homeostasis in joints affected by osteoarthritis (OA). However, the specific mechanism of non-SMAD and classical SMAD signaling interactions is still unclear, which needs to be further explored.<bold>Methods: </bold>In ATDC5 cells, USP15 overexpression and knockout...
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Identifiers and source
- Literature Corpus work
- 7a4887be-fcf2-5f50-ae8d-558c91aac23d
- DOI
- 10.21203/rs.3.rs-93713/v2