Article

The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

2023-07-26

Abstract excerpt

<title>Abstract</title><p>BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified. However, the deubiquitinating enzyme for BRCA1 remains less defined. Here, we report that the deubiquitinase USP4 interacts with, deubiquitinates and stabilizes BRCA1, maintaining...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d626c232-5371-526b-89b4-1e819b015d1f
DOI: 10.21203/rs.3.rs-3104760/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinating enzyme USP4 regulates BRCA1 stability and functionDOI 10.21203/rs.3.rs-3104760/v1Read

The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progressionSemantic proximity Read

USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary cells to suppress breast cancerSemantic proximity Read

Targeting deubiquitinase USP28 for cancer therapySemantic proximity Read

The role of USP1 deubiquitinase in the pathogenesis and therapy of cancerSemantic proximity Read

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.Semantic proximity Read

The Deubiquitin Enzyme USP28 Maintains the Viability of Triple Negative Breast Cancer Cells through Stabilizing the RecQ Family HelicasesSemantic proximity Read

Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatmentSemantic proximity Read

Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatmentSemantic proximity Read

A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer.Semantic proximity Read

USP3 : Key deubiquitylation enzyme in human diseasesSemantic proximity Read

The deubiquitinating enzyme USP24 is a regulator of the UV damage response.Semantic proximity Read

Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer developmentSemantic proximity Read