Article

USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary cells to suppress breast cancer

2023-05-22

Abstract excerpt

<h4>Background: </h4> Basal-like breast cancer may originate from luminal epithelial or cancerous cells. Inadequately repaired DNA damage impairs luminal differentiation and promotes aberrant luminal to basal trans-differentiation in mammary epithelial cells. USP11, a deubiquitinase, plays a critical role in DNA damage repair. The role of USP11 in controlling mammary cell differentiation and tumorigenesis remains...

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Literature Corpus work: ac9f03a9-5f93-5799-9738-a601a76e9ed4
DOI: 10.21203/rs.3.rs-2934755/v1

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