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Article

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta

4 Feb 2019

Abstract excerpt

USP22, a component of the SAGA complex, is overexpressed in highly aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We determined that loss of USP22 in mice results in embryonic lethality due to defects in extra-embryonic placental tissues and failure to establish proper vascular interactions with the maternal circulatory system. These phenotypes arise from abnormal gene...

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PMID: 30718289
DOI: 10.1242/dev.174037

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