Article

Differential contributions of circadian clock genes to cell survival in bipolar disorder patient derived neuronal progenitor cells distinguishes lithium responders and non-responders

2024-04-30

Abstract excerpt

<title>Abstract</title> <p>Bipolar disorder (BD) is characterized by disrupted circadian rhythms and neuronal loss. Lithium is neuroprotective and used to treat BD, but outcomes are variable. Past research identified that circadian rhythms in BD patient neurons are associated with lithium response (Li-R) or non-response (Li-NR). However, the underlying cellular mechanisms remain unknown. To study interactions amo...

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Literature Corpus work: c718056b-bab3-5a2f-8a9e-82fa90619a65
DOI: 10.21203/rs.3.rs-4331810/v1

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