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Article

Lithium response in bipolar disorder correlates with improved cell viability of patient derived cell lines.

Scientific reports - 4 May 2020

Paul Pradip, Iyer Shruti, Nadella Ravi Kumar, Nayak Rashmitha, Chellappa Anirudh S, Ambardar Sheetal, Sud Reeteka, Sukumaran Salil K, Purushottam Meera, Jain Sanjeev, Viswanath Biju

Abstract excerpt

Lithium is an effective, well-established treatment for bipolar disorder (BD). However, the mechanisms of its action, and reasons for variations in clinical response, are unclear. We used neural precursor cells (NPCs) and lymphoblastoid cell lines (LCLs), from BD patients characterized for clinical response to lithium (using the "Alda scale" and "NIMH Retrospective Life chart method"), to interrogate cellular...

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Identifiers

PMID: 32366893
DOI: 10.1038/s41598-020-64202-1
PMCID: PMC7198534

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