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Article

Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines.

The pharmacogenomics journal - 1 Oct 2016

Breen M S, White C H, Shekhtman T, Lin K, Looney D, Woelk C H, Kelsoe J R

Abstract excerpt

Lithium (Li) is the mainstay mood stabilizer for the treatment of bipolar disorder (BD), although its mode of action is not yet fully understood nor is it effective in every patient. We sought to elucidate the mechanism of action of Li and to identify surrogate outcome markers that can be used to better understand its therapeutic effects in BD patients classified as good (responders) and poor responders...

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Identifiers

PMID: 27401222
DOI: 10.1038/tpj.2016.50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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