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Article

Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder.

Genes, brain, and behavior - 1 Nov 2011

McCarthy M J, Nievergelt C M, Shekhtman T, Kripke D F, Welsh D K, Kelsoe J R

Abstract excerpt

Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and daily activity that often normalize after lithium treatment in responsive patients. As lithium is known to interact with the circadian clock, we hypothesized that variation in circadian 'clock genes' would be associated with lithium response in BD. We determined genotype for 16 variants in seven circadian clock genes and...

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Source

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Identifiers

PMID: 21781277
DOI: 10.1111/j.1601-183X.2011.00725.x
PMCID: PMC3461952

Genes

CRY1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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