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Article

Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder.

Genes, brain, and behavior - 1 Nov 2011

McCarthy M J, Nievergelt C M, Shekhtman T, Kripke D F, Welsh D K, Kelsoe J R

Abstract excerpt

Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and daily activity that often normalize after lithium treatment in responsive patients. As lithium is known to interact with the circadian clock, we hypothesized that variation in circadian 'clock genes' woul...

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Identifiers

PMID: 21781277
DOI: 10.1111/j.1601-183X.2011.00725.x
PMCID: PMC3461952

Genes

CRY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21781277-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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