Article

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology

2023-12-10

Abstract excerpt

<h4>SUMMARY</h4> Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their fragile structures. However, whether a modification that stabilizes a wild-type (WT) mt-tRNA structure would also stabilize its pathogenic variants is unknown....

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Literature Corpus work: 6aef4595-8791-52b5-89b6-aa7726f07271
DOI: 10.1101/2023.12.09.569632

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