Article

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

2025-01-22

Abstract excerpt

Frailty is an age-related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male (n = 47) C57BL/6NIA mice, measured frailty index and derived metabolomics data from plasma samples. We identify differentially abundant metabolites related to aging, determine frailty related metabolites via a machine learning approach, and generate a un...

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Literature Corpus work: 92caf0c4-6757-53d6-8933-7ffad35947f3
DOI: 10.1101/2025.01.22.634160

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