Article

Substrate stiffness dictates unique paths towards proliferative arrest in WI-38 cells

2024-09-26

Abstract excerpt

Finite replicative potential is a defining feature of non-transformed somatic cells, first established by Leonard Hayflick in vitro using WI-38 human lung fibroblasts. Once proliferative capacity is exhausted due to telomere shortening, cells enter into a state called replicative senescence, which can be avoided through ectopic expression of telomerase reverse transcriptase (hTERT). As WI-38 cells approach replic...

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Literature Corpus work: c6d632b5-726b-5844-8d20-05dd3e128e02
DOI: 10.1101/2024.09.24.614744

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