Article

Substrate stiffness controls the cell cycle of human mesenchymal stem cells via cellular traction

2021-11-20

Abstract excerpt

The microenvironment of human mesenchymal stem cells (hMSCs) regulates their self-renewal and differentiation properties. Previously it was shown that hMSCs remained quiescent on soft (0.25 kPa) polyacrylamide (PA) gels but re-entered into cell cycle on a stiff (7.5 kPa) gel. However, how cells behave on intermediate stiffness and what intracellular factors transmit mechanical changes to cell interior thereby regu...

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Literature Corpus work: f76bbd60-2f0e-5c38-9b8d-40a8cbc2e3a9
DOI: 10.1101/2021.11.19.469207

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