Article

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

2023-12-23

Abstract excerpt

Loss of function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-onset Parkinson’s disease (PD). Stabilisation of PINK1 at the Translocase of Outer Membrane (TOM) complex of damaged mitochondria is a critical step for its activation. To date the mechanism of how PINK1 is activated in the TOM complex is unclear. Herein we report co-expression of human PINK1 and all seven TOM subunits in Sa...

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Literature Corpus work: c6ca64ac-d8d3-555b-b150-59591a3ae79d
DOI: 10.1101/2023.12.23.573181

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