Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling.

Biochemical Society transactions - 1 Apr 2015

Rüb Cornelia, Schröder Nadja, Voos Wolfgang

Abstract excerpt

Defects of mitochondrial functions have been implicated in many different human diseases, in particular neurodegenerative diseases. The kinase PINK1 [phosphatase and tensin homologue (PTEN)-induced kinase 1] has been identified as a crucial player in a specific damage signalling pathway, eliminating defective mitochondria by an autophagic process. Mutations in PINK1 have been shown to cause familial cases of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PINK1 gene
Share to PTEN gene
Share to Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Share to Protein Kinases

Share to Signal Transduction

Source

Identifiers

PMID: 25849931
DOI: 10.1042/BST20150005

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling.PMID 25849931Read ↗

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).Semantic proximity Read ↗

PINK1 function in health and disease.Semantic proximity Read ↗

Function and characteristics of PINK1 in mitochondria.Semantic proximity Read ↗

The mitochondrial kinase <scp>PINK</scp>1: functions beyond mitophagySemantic proximity Read ↗

The emerging multifaceted role of PINK1 in cancer biologySemantic proximity Read ↗

PINK1 in the limelight: multiple functions of an eclectic protein in human health and diseaseSemantic proximity Read ↗

Mechanisms Associated with PINK1 Mutations in Parkinson's DiseaseSemantic proximity Read ↗

A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.Semantic proximity Read ↗

Genetic mutations and functions of PINK1.Semantic proximity Read ↗

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s DiseaseSemantic proximity Read ↗

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)Semantic proximity Read ↗

Mitochondrial-Dependent and Independent Functions of PINK1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.