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Article

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.

Journal of cell science - 1 Mar 2015

Okatsu Kei, Kimura Mayumi, Oka Toshihiko, Tanaka Keiji, Matsuda Noriyuki

Abstract excerpt

Dysfunction of PTEN-induced putative kinase 1 (PINK1), a Ser/Thr kinase with an N-terminal mitochondrial-targeting sequence (MTS), causes familial recessive parkinsonism. Reduction of the mitochondrial membrane potential limits MTS-mediated matrix import and promotes PINK1 accumulation on the outer mitochondrial membrane (OMM) of depolarized mitochondria. PINK1 then undergoes autophosphorylation and...

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Source

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Identifiers

PMID: 25609704
DOI: 10.1242/jcs.161000
PMCID: PMC4342580

Genes

PINK1
PTEN
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.PMID 25609704Read ↗

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Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality ControlSemantic proximity Read ↗

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