Article
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Autophagy - 1 Nov 2013
Bertolin Giulia, Ferrando-Miguel Rosa, Jacoupy Maxime, Traver Sabine, Grenier Karl, Greene Andrew W, Dauphin Aurélien, Waharte François, Bayot Aurélien, Salamero Jean, Lombès Anne, Bulteau Anne-Laure, Fon Edward A, Brice Alexis, Corti Olga
Abstract excerpt
Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-dependent recruitment of PARK2 to the outer mitochondrial membrane (OMM), followed by the...
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