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Article

The genome as pharmacopeia: association of genetic dose with phenotypic response.

Biochemical pharmacology - 15 Apr 2015

Wadhawan Samir, Runz Heiko, Burchard Julja

Abstract excerpt

The majority of compounds that enter clinical trials fail to meet regulatory standards for marketed therapeutics. Success in clinical trials is increased when therapies are directed against targets for which genetic variants have been linked to disease risk or progression in humans. Here we review how genome-wide association studies (GWAS) have furthered our understanding of the genetic basis of common disease,...

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PMID: 25707983
DOI: 10.1016/j.bcp.2015.02.005

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