Article
Characterizing the genetic architecture of drug response using gene-context interaction methods.
Cell genomics - 11 Dec 2024
Sadowski Michal, Thompson Mike, Mefford Joel, Haldar Tanushree, Oni-Orisan Akinyemi, Border Richard, Pazokitoroudi Ali, Cai Na, Ayroles Julien F, Sankararaman Sriram, Dahl Andy W, Zaitlen Noah
Abstract excerpt
Identifying factors that affect treatment response is a central objective of clinical research, yet the role of common genetic variation remains largely unknown. Here, we develop a framework to study the genetic architecture of response to commonly prescribed drugs in large biobanks. We quantify treatment response heritability for statins, metformin, warfarin, and methotrexate in the UK Biobank. We find that...
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