Article
Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual's drug responses.
Pharmacogenomics - 1 Oct 2010
Feng Junjie, Sun Jielin, Wang Michael Zhuo, Zhang Zheng, Kim Seong-Tae, Zhu Yi, Sun Jishan, Xu Jianfeng
Abstract excerpt
AIMS: Polymorphisms of genes involved in the pharmacokinetic and pharmacodynamic processes underlie the divergent drug responses among individuals. Despite some successes in identifying these polymorphisms, the candidate gene approach suffers from insufficient gene coverage whereas the genome-wide association approach is limited by less than ideal coverage of SNPs in some important genes. To expand the potential...
Topics
- Databases, Genetic
- Drug-Related Side Effects and Adverse Reactions
- Genetic Association Studies
- Genetic Variation
- Genome-Wide Association Study
- Genotype
- Humans
- MicroRNAs
- Pharmaceutical Preparations
- Pharmacogenetics