Article

Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis.

2025-03-30

Abstract excerpt

Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, is preceded by an early period unrelated to the motor system, including altered sleep, with increased wake and decreased NREM sleep phases. Whether these alterations in sleep macroarchitecture are associated, or even preceded by abnormalities in sleep-related EEG hallmarks is unknown. Here we used polysomnography to characterize sleep...

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Literature Corpus work: 81da382a-4401-5cc6-a852-40577e99b9b7
DOI: 10.1101/2025.03.28.25324779

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