Article

Sleep is bi-directionally modified by amyloid beta oligomers

2019-04-16

Abstract excerpt

<h4>SUMMARY</h4> Disrupted sleep is a major feature of Alzheimer’s Disease (AD), often arising years before symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of amyloid-beta (Aβ) species, a major driver of AD progression, suggesting that sleep loss further accelerates AD through a vicious cycle. However, the mechanisms by which Aβ affects sleep are unknown. We demonstrate in zebrafis...

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Literature Corpus work: 179d4e59-1375-535b-b93a-7e06b9f95435
DOI: 10.1101/610014

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