Article
The Prognostic Role of Obstructive Sleep Apnea at the Onset of Amyotrophic Lateral Sclerosis.
Neuro-degenerative diseases - 1 Jan 2017
Quaranta Vitaliano Nicola, Carratù Pierluigi, Damiani Mario Francesco, Dragonieri Silvano, Capozzolo Alberto, Cassano Anna, Resta Onofrio
Abstract excerpt
BACKGROUND/OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of central and peripheral motor neurons. Some studies have found discordant data in the presence of sleep apnea in ALS patients. An obstructive component also occurs with upper airways hypotonia and muscle weakness that may result in an excessive reduction of airway lumen, leading to...
Topics
- Aged
- Amyotrophic Lateral Sclerosis
- Early Diagnosis
- Female
- Follow-Up Studies
- Humans
- Inhalation
- Kaplan-Meier Estimate
- Linear Models
- Longitudinal Studies
- Male