Article

Orbitofrontal-hypothalamic projections are disrupted in hypermetabolic murine ALS model and human patients

2020-11-28

Abstract excerpt

Increased catabolism is a new clinical manifestation of Amyotrophic Lateral Sclerosis. A dysfunction of lateral hypothalamus may drive hypermetabolism in ALS; however, Its causes and anatomical substrates are unknown. We hypothesize that disruption cortico-hypothalamic circuits may impair energy homeostasis in ALS. We used rAAV2 for large-scale projection mapping and image analysis pipeline based on Wholebrain and...

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Literature Corpus work: 31f96146-5c0b-5a63-be56-882dbde23625
DOI: 10.1101/2020.11.28.402065

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Orbitofrontal-hypothalamic projections are disrupted in hypermetabolic murine ALS model and human patientsDOI 10.1101/2020.11.28.402065Read

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