Genetic ALS-Progressive Sleep Defects Precede the Onset of Clinical Disease.

Abstract excerpt

BACKGROUND: The onset of amyotrophic lateral sclerosis (ALS) is preceded by non-motor signs detectable many years before motor symptom onset. We recently showed that early ALS patients and presymptomatic carriers of ALS-associated gene mutations display altered sleep macroarchitecture, characterised by increased wakefulness and decreased non-REM sleep, together with altered microarchitecture, particularly reduced...

Topics

• Humans
• Amyotrophic Lateral Sclerosis
• Female
• Male
• Polysomnography
• Disease Progression