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mRNA Localization: An Orchestration of Assembly, Traffic and Synthesis

22 Aug 2012

Abstract excerpt

Asymmetrical mRNA localization and subsequent local translation provide efficient mechanisms for protein sorting in polarized cells. Defects in mRNA localization have been linked to developmental abnormalities and neurological diseases. Thus, it is critical to understand the machineries mediating and mechanisms underlying the asymmetrical distribution of mRNA and its regulation. The goal of this review is to...

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PMID: 22913533
DOI: 10.1111/tra.12004

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