Article

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

2021-01-06

Abstract excerpt

Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and transmission 1-4 . The mechanisms that protect them from stress-induced death and degeneration remain elusive. Here we show that embryonic deletion of the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons or hair cells leads to sensorineural hearing loss due...

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Literature Corpus work: c67d6b30-b834-54fb-838d-17fd08b93d72
DOI: 10.1101/2021.01.05.425431

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