Article

<i>Let-7</i> miRNAs control auditory sensory progenitor behavior in the vertebrate inner ear

2019-05-31

Abstract excerpt

<h4>ABSTRACT</h4> The evolutionary conserved lethal-7 ( let-7 ) family of microRNAs (miRNAs) is a well-known activator of terminal mitosis and differentiation. Surprisingly, we previously found that overexpression of let-7 miRNAs in the murine auditory organ accelerated the terminal mitosis of auditory sensory progenitors (pro-sensory cells) but failed to stimulate their differentiation into mechano-sensory hai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e6875d8-ae1d-589f-839f-95df1563346a
DOI: 10.1101/655993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Let-7</i> miRNAs control auditory sensory progenitor behavior in the vertebrate inner earDOI 10.1101/655993Read

let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner earSemantic proximity Read

CHD7 regulates otic lineage differentiation and deafness gene expression in human inner ear organoidsSemantic proximity Read

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degenerationSemantic proximity Read

Development of the Mouse and Human Cochlea at Single Cell ResolutionSemantic proximity Read

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.Semantic proximity Read

Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures.Semantic proximity Read

Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.Semantic proximity Read

Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome.Semantic proximity Read

Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathwaysSemantic proximity Read

Chromodomain proteins in development: lessons from CHARGE syndromeSemantic proximity Read

DNA methylation dynamics during embryonic development and postnatal maturation of the mouse auditory organ of CortiSemantic proximity Read

The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner earSemantic proximity Read