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Article

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

20 Mar 2017

Abstract excerpt

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal cerebellar development. Genetic inactivation of Chd7 in cerebellar granule neuron progenitors leads to cerebellar hypoplasia in mice, due to the impairment of...

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PMID: 28317875
DOI: 10.1038/ncomms14758

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Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programmePMID 28317875Read ↗

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