Article

CHD7 regulates otic lineage differentiation and deafness gene expression in human inner ear organoids

2021-12-03

Abstract excerpt

<title>Abstract</title> <p>Mutations in the chromatin remodeling enzyme CHD7 cause CHARGE syndrome, which affects multiple organs including the inner ear. We investigated how CHD7 mutations affect otic development in human inner ear organoids. We found loss of CHD7 or its chromatin remodeling activity leads to complete absence of hair cells and supporting cells, which can be explained by dysregulation of key otic...

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Literature Corpus work: 046061b3-2d27-5194-8746-0e3056af016c
DOI: 10.21203/rs.3.rs-1132148/v1

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