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Article

Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome.

Hearing research - 1 Dec 2011

Hurd Elizabeth A, Adams Meredith E, Layman Wanda S, Swiderski Donald L, Beyer Lisa A, Halsey Karin E, Benson Jennifer M, Gong Tzy-Wen, Dolan David F, Raphael Yehoash, Martin Donna M

Abstract excerpt

Heterozygous mutations in the gene encoding chromodomain-DNA-binding-protein 7 (CHD7) cause CHARGE syndrome, a multiple anomaly condition which includes vestibular dysfunction and hearing loss. Mice with heterozygous Chd7 mutations exhibit semicircular canal dysgenesis and abnormal inner ear neurogenesis, and are an excellent model of CHARGE syndrome. Here we characterized Chd7 expression in mature middle and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21875659
DOI: 10.1016/j.heares.2011.08.005
PMCID: PMC3230679

Genes

ABR
CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome.PMID 21875659Read ↗

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