Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.

Communications biology - 3 Nov 2021

Ahmed Mohi, Moon Ruth, Prajapati Ravindra Singh, James Elysia, Basson M Albert, Streit Andrea

Abstract excerpt

Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and transmission. The mechanisms that protect them from stress-induced death and degeneration remain elusive. Here we show that embryonic deletion of the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons or hair cells leads to sensorineural hearing loss due to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 34732824
DOI: 10.1038/s42003-021-02788-6
PMCID: PMC8566505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.PMID 34732824Read ↗

The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degenerationSemantic proximity Read ↗

CHD7 regulates otic lineage differentiation and deafness gene expression in human inner ear organoidsSemantic proximity Read ↗

Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome.Semantic proximity Read ↗

let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner earSemantic proximity Read ↗

<i>Let-7</i> miRNAs control auditory sensory progenitor behavior in the vertebrate inner earSemantic proximity Read ↗

Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures.Semantic proximity Read ↗

Chromodomain proteins in development: lessons from CHARGE syndromeSemantic proximity Read ↗

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.Semantic proximity Read ↗

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programmeSemantic proximity Read ↗

Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and DiseaseSemantic proximity Read ↗

CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expressionSemantic proximity Read ↗

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.