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Article

Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.

Mechanisms of development - 1 Jan 2000

Hurd Elizabeth A, Micucci Joseph A, Reamer Elyse N, Martin Donna M

Abstract excerpt

Proper morphogenesis of inner ear semicircular canals requires precise regulation of cellular proliferation, epithelial-to-mesenchymal transition, and fusion of epithelial plates. Epigenetic regulation of these processes is not well understood, but is likely to involve chromatin remodeling enzymes. CHD7 is a chromodomain-containing, ATP dependent helicase protein that is highly expressed in the developing ear and...

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Identifiers

PMID: 22705977
DOI: 10.1016/j.mod.2012.06.002
PMCID: PMC3477510

Genes

CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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