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Article

A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA.

BMC bioinformatics - 3 Apr 2020

Wu Leilei, Deng Qinfang, Xu Ze, Zhou Songwen, Li Chao, Li Yi-Xue

Abstract excerpt

BACKGROUND: Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are still a great challenge. In addition, no panel-wide calling algorithm is available, which hiders the full usage of ctDNA based 'liquid biopsy'. Thus, we developed the VBCALAVD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32245364
DOI: 10.1186/s12859-020-3412-2
PMCID: PMC7118954

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