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Article

A comprehensive database for identifying and interpreting ctDNA driver genes and variants in cancer.

Scientific data - 16 Jul 2025

Wang Yuncong, Gan Jing, Hu Haoyu, Xu Manyi, Xu Yongle, Zhao Yusen, Dong Wenbo, Li Xinrong, Zhu Hongbo, Wang Shuangshuang, He Jiaheng, Ning Shangwei, Wang Peng, Zhi Hui

Abstract excerpt

Circulating tumor DNA (ctDNA) variants hold significant promise as cancer biomarkers in liquid biopsies, owing to their minimally invasive testing approach and capacity to capture the comprehensive tumor landscape. However, a comprehensive resource for studying ctDNA variants is still lacking. Here, we developed CTDdgv to systematically identify ctDNA variants and interpret their clinical relevance. We manually...

Read the complete abstract on PubMed

Topics

Humans
Neoplasms
Circulating Tumor DNA
Biomarkers, Tumor
Mutation
Databases, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Liquid Biopsy

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Identifiers

PMID: 40670358
DOI: 10.1038/s41597-025-05550-3
PMCID: PMC12267690

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