Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beyond basics: Key mutation selection features for successful tumor-informed ctDNA detection.

International journal of cancer - 1 Sept 2024

Nesic Marijana, Rasmussen Mads H, Henriksen Tenna V, Demuth Christina, Frydendahl Amanda, Nordentoft Iver, Dyrskjøt Lars, Andersen Claus L

Abstract excerpt

Tumor-informed mutation-based approaches are frequently used for detection of circulating tumor DNA (ctDNA). Not all mutations make equally effective ctDNA markers. The objective was to explore if prioritizing mutations using mutational features-such as cancer cell fraction (CCF), multiplicity, and error rate-would improve the success rate of tumor-informed ctDNA analysis. Additionally, we aimed to develop a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circulating Tumor DNA

Share to Cohort Studies

Share to Colorectal Neoplasms

Share to DNA Mutational Analysis

Share to Exome Sequencing

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 38623608
DOI: 10.1002/ijc.34964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beyond basics: Key mutation selection features for successful tumor-informed ctDNA detection.PMID 38623608Read ↗

Challenges in Using ctDNA to Achieve Early Detection of CancerSemantic proximity Read ↗

Combining mutation detection with fragmentomics features leads to improved tumor-informed ctDNA detectionSemantic proximity Read ↗

Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosisSemantic proximity Read ↗

Baseline mutation profiling of 1134 samples of circulating cell-free DNA and blood cells from healthy individualsSemantic proximity Read ↗

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.Semantic proximity Read ↗

NGS-Based Tumor-Informed Analysis of Circulating Tumor DNA.Semantic proximity Read ↗

Circulating tumor DNA profiling approach based on in silico background elimination guides patient classification of multiple cancersSemantic proximity Read ↗

Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.Semantic proximity Read ↗

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types.Semantic proximity Read ↗

The potential of combined mutation sequencing of plasma circulating cell-free DNA and matched white blood cells for treatment response prediction.Semantic proximity Read ↗

Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden.Semantic proximity Read ↗

Concordance between whole exome sequencing of circulating tumor DNA and tumor tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.