Article
Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2020
Shi Ruoshi, Radulovich Nikolina, Ng Christine, Liu Ni, Notsuda Hirotsugu, Cabanero Michael, Martins-Filho Sebastiao N, Raghavan Vibha, Li Quan, Mer Arvind Singh, Rosen Joshua C, Li Ming, Wang Yu-Hui, Tamblyn Laura, Pham Nhu-An, Haibe-Kains Benjamin, Liu Geoffrey, Moghal Nadeem, Tsao Ming-Sound
Abstract excerpt
PURPOSE: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. There is an unmet need to develop novel clinically relevant models of NSCLC to accelerate identification of drug targets and our understanding of the disease. EXPERIMENTAL DESIGN: Thirty surgically resected NSCLC primary patient tissue and 35 previously established patient-derived xenograft (PDX) models were...
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