Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

doi:10.1200/JCO.2014.60.1492

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Article

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2015

Stewart Erin L, Mascaux Celine, Pham Nhu-An, Sakashita Shingo, Sykes Jenna, Kim Lucia, Yanagawa Naoki, Allo Ghassan, Ishizawa Kota, Wang Dennis, Zhu Chang-Qi, Li Ming, Ng Christine, Liu Ni, Pintilie Melania, Martin Petra, John Tom, Jurisica Igor, Leighl Natasha B, Neel Benjamin G, Waddell Thomas K, Shepherd Frances A, Liu Geoffrey, Tsao Ming-Sound

Abstract excerpt

PURPOSE: Although epidermal growth factor receptor (EGFR) -mutated adenocarcinomas initially have high response rates to EGFR tyrosine kinase inhibitors (TKIs), most patients eventually develop resistance. Patient-derived xenografts (PDXs) are considered preferred preclinical models to study the biology of patient tumors. EGFR-mutant PDX models may be valuable tools to study the biology of these tumors and to...

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PMID: 26124487
DOI: 10.1200/JCO.2014.60.1492

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EGFR

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