Article
Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies.
Journal of translational medicine - 10 Jul 2013
Zhang Xu-chao, Zhang Jingchuan, Li Ming, Huang Xiao-sui, Yang Xue-ning, Zhong Wen-zhao, Xie Liang, Zhang Lin, Zhou Minhua, Gavine Paul, Su Xinying, Zheng Li, Zhu Guanshan, Zhan Ping, Ji Qunsheng, Wu Yi-long
Abstract excerpt
BACKGROUND: Patient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) xenograft mouse models are relatively few in number and are limited in their degree of genetic characterization and validation. In this study, we aimed to establish a variety of patient-derived...
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