Article

Rescuing Epileptic and Behavioral Alterations in a Dravet Syndrome Mouse Model by Inhibiting Eukaryotic Elongation Factor 2 Kinase (eEF2K)

2021-08-04

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the <italic>SCN1A</italic> gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (NaV1.1), that cause imbalance between excitation and inhibition in the brain. We recently found that eEF2K knock out mice displayed enhan...

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Literature Corpus work: c62490ef-6b6a-5e84-96b4-0abaa9cbc100
DOI: 10.21203/rs.3.rs-762945/v1

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