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Article

A novel rat model of Dravet syndrome recapitulates clinical hallmarks

8 Jun 2023

Abstract excerpt

Dravet syndrome (DS) is a debilitating infantile epileptic encephalopathy characterized by seizures induced by high body temperature (hyperthermia), sudden unexpected death in epilepsy (SUDEP), cognitive impairment, and behavioral disturbances. The most common cause of DS is haploinsufficiency of the SCN1A gene, which encodes the voltage-gated sodium channel Nav1.1. In current mouse models of DS, the epileptic...

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PMID: 37295561
DOI: 10.1016/j.nbd.2023.106193

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