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Neurodevelopmental defects in Dravet syndrome <i>Scn1a</i> <sup>+/-</sup> mice: targeting GABA-switch rescues behavioral dysfunctions but not seizures and mortality

2024-03-07

Abstract excerpt

Dravet syndrome (DS) is a developmental and epileptic encephalopathy (DEE) caused by mutations of the SCN1A gene (Na V 1.1 sodium channel) and characterized by seizures, motor disabilities and cognitive/behavioral deficits, including autistic traits. The relative role of seizures and neurodevelopmental defects in disease progression, as well as the role of the mutation in inducing early neurodevelopmental defect...

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Literature Corpus work
1c4e5b88-7233-5689-9c4e-341c68ce7246
DOI
10.1101/2024.03.06.583652
Open publication

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