Article

Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic eEF2K

2021-07-09

Abstract excerpt

Dravet Syndrome is a severe childhood pharmacoresistant epileptic disorder caused mainly by mutations in the SCN1A gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (Na V 1.1), that cause imbalance between excitation and inhibition in the brain. We recently found that eEF2K knock out mice displayed enhanced GABAergic transmission and tonic inhibition and were less susceptible to e...

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Literature Corpus work: 1d62000e-9c67-53dc-9a0b-4439a2ec9334
DOI: 10.1101/2021.07.07.451562

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