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Spatially-resolved single cell atlas of liposarcoma reveals lineage hierarchies, immune niches, and regulatory circuits

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Well-differentiated and dedifferentiated liposarcoma (WDLPS and DDLPS) exhibit markedly different clinical behaviors, with DDLPS showing greater aggressiveness, higher recurrence and metastasis rates, and worse outcomes. Using single-nucleus multiome sequencing, epigenomic profiling, and spatial transcriptomics, we characterized cellular and epigenetic heterogeneity between these subtypes at sin...

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Literature Corpus work
ddbd0c2e-0cf5-5fc0-b0d0-975d07cf7baa
DOI
10.64898/2026.03.23.713651
Open publication

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