Article

Proteomic profiling of the neuroblastoma secretome identifies extracellular vesicles as drivers of T cell suppression

2025-12-03

Abstract excerpt

Immunosuppressive tumor microenvironments in solid tumors hamper the efficacy of immunotherapies, including CAR T-cell therapy. To identify immunosuppressive secreted factors in high-risk neuroblastoma, a childhood solid tumor with a 5-year overall survival of below 60%, we mapped secreted factors of 16 genetically diverse patient-derived neuroblastoma tumoroids by LC-MS. The secretomes suppressed T cell activatio...

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Literature Corpus work: f9aaf064-9746-58e1-b361-3e791a8c8a2f
DOI: 10.64898/2025.12.02.690421

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