Article

Therapy-induced senescent-like cancer cells drive macrophage-mediated immunosuppression in cholangiocarcinoma

2026-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Cholangiocarcinoma (CCA) is a lethal biliary cancer in which chemoresistance is nearly universal, and its tumor immune microenvironment is dominated by immunosuppressive tumor-associated macrophages (TAMs) that exclude cytotoxic CD8 + T cells. How tumor cells sustain this immunosuppressive state during chemotherapy is undefined. Here we demonstrate that therapy-induced senescent-like (Sen-L) ca...

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Literature Corpus work: de847e04-853a-5d4a-92c4-704de3f34e9f
DOI: 10.64898/2026.06.24.734341

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