Article

From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval

2025-05-29

Abstract excerpt

<h4>Motivation</h4> Large-scale drug sensitivity screens have enabled training drug response prediction models based on cancer cell line omics profiles to facilitate personalized medicine. While model performances reported in the literature appear promising, no successful translation to the clinic has been reported. <h4>Results</h4> We identify six primary obstacles to this: non-reproducible models, data leakage...

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Literature Corpus work: 45ac674b-6efd-5f57-a8b5-caf876589e59
DOI: 10.1101/2025.05.26.655288

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