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Article

A hyperactive piggyBac transposase for mammalian applications.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Yusa Kosuke, Zhou Liqin, Li Meng Amy, Bradley Allan, Craig Nancy L

Abstract excerpt

DNA transposons have been widely used for transgenesis and insertional mutagenesis in various organisms. Among the transposons active in mammalian cells, the moth-derived transposon piggyBac is most promising with its highly efficient transposition, large cargo capacity, and precise repair of the donor site. Here we report the generation of a hyperactive piggyBac transposase. The active transposition of piggyBac...

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Identifiers

PMID: 21205896
DOI: 10.1073/pnas.1008322108
PMCID: PMC3029773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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