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Article

DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

Jin Yan, Chen Yaohui, Zhao Shimin, Guan Kun-Liang, Zhuang Yuan, Zhou Wenhao, Wu Xiaohui, Xu Tian

Abstract excerpt

The involvement of host factors is critical to our understanding of underlying mechanisms of transposition and the applications of transposon-based technologies. Modified piggyBac (PB) is one of the most potent transposon systems in mammals. However, varying transposition efficiencies of PB among different cell lines have restricted its application. We discovered that the DNA-PK complex facilitates PB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28645898
DOI: 10.1073/pnas.1612980114
PMCID: PMC5514698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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